[Dependence of biological activity of triamine type platinum (II) complexes on their composition and structure]. / Zavisimost' biologicheskoi aktivnosti kompleksov platiny(II) triaminovogo tipa ot ikh sostava i stroeniia.

The growth-inhibiting effect on the roots of maize and cucumber shoots was studied. We tested 53 triamine complexes of platinum (cis*- and trans*-[Pt(NH3)*2LCl]Cl, cis*- and trans*-[PtHx*2LCl]Cl and [PtenLCl]Cl, where Hx is hydroxylamine, en is ethylenediamine, and L are various heterocycles, which either have biological activity and occur in the cells or have no biological activity and are foreign to the cells). The cis*-[Pt(NH3)*2LCl]Cl and [PtenLCl]Cl complexes showed cytostatic properties, and the latter were effective at higher concentrations. Small changes in the composition of ligand L led to marked changes in the biological activity of the complexes. In order to characterize the effect of the complexes, we first determined the time of development of the lateral root from its initial appearance to its divergence from the main root (Tlat). The complexes with cytostatic properties markedly inhibited root branching and increased Tlat. The other complexes had virtually no effect on Tlat and reduced the zone of lateral roots only at the expense of inhibition of the main root growth. The complexes with cytostatic properties markedly inhibited the main root growth with time. Parallel studies conducted in the Oncological Research Center, Russian Academy of Medical Sciences have shown that the complexes with cytostatic properties display distinct antitumor activity.

[Experimental estimation of the effect of antibiotics, immobilized on the surface of titanium implant, on the development of the inflammatory process]. / Eksperimental'naia otsenka vliianiia antibiotikov, immobilizovannykh na poverkhnost' titanovogo implantata, na razvitie vospalitel'nogo protsessa.

Titanium implants with immobilized lincomycin and ampicillin were studied on rats with respect to the effect on development of inflammatory reactions. The data on the concentrations of sialic acids in the blood during the postoperative period and the histological examinations showed that lower concentrations of sialic acids, early fibroblastic reaction, productive nature of inflammation in the main and rapid formation of the fibrous connective tissue capsule around the implants were the characteristic features and advantages of the use of the implants with the immobilized antibiotics as compared to the use of the routine titanium implants.

[Immobilization of antibiotics on a titanium surface]. / Immobilizatsiia antibiotikov na poverkhnosti titana.

Immobilization of antibiotics on the surface of electrolytically oxidated titanium was tried. Transfer of the immobilized ampicillin into hardly soluble calcium ampicillate resulted in providing the coating with antimicrobial activity for 5 days. The quantity of the immobilized antibiotic determined polarographically amounted to 6.4.10(-3) mol per 1 m2 of the surface.

[Increase in the effectiveness of microbial absorption on activated charcoal upon sorbent polarization]. / Povyshenie éffektivnosti sorbtsii mikroorganizamov na aktivirovannom ugle pri poliarizatsii sorbenta.

The effect of Staphylococcus albus and the contact time on hydrolytic adsorption of ions on activated charcoal SKN-2K in the physiological solution (0.9% NaCl) was investigated. Experiments were performed without polarization or with cathodic and anodic polarization of the adsorbent. The adsorbed microorganisms decreased the rate of electrolyte ion adsorption, especially in case of cathodic polarization. When activate charcoal was at negative potential (-0.2 V), up to 95% of active microorganisms was adsorbed at the initial concentration of 5.75.10(6) microorganisms per ml, while in case of anodic polarization only 43-44% of microorganisms was adsorbed.

[Immobilization of invertase in polyvinyl alcohol coatings]. / Immobilizatsiia invertazy v pokrytie iz polivinilovogo spirta.

A possibility of invertase immobilization in the polyvinyl alcohol coating formed directly on the electrode surface from water solution of polyvinyl alcohol and boric acid was being investigated. Conditions for obtaining the polymeric coating at the constant potential and at the constant current were compared. In order to obtain the polymeric coatings with a marked enzyme activity optimal conditions were found.

[Electrochemical immobilization of glucose oxidase in the polyacrylamide coating in the presence of glutaraldehyde]. / Elektrokhimicheskaia immobilizatsiia gliukozoksidazy v poliakrilamidnoe pokrytie v prisutstvii glutarovogo al'degida.

A new electrolyte composition for preparing polyacrylamide coatings with immobilized glucose oxidase that contains glutaraldehyde as a component is proposed. The polarographic behaviour of glutaraldehyde at increased ZnCl2 concentrations answers the criterion of electrochemical polymerization. Glutaraldehyde improves cross-linkage within polyacrylamide, provides an increase of the coating mass and its better quality and adherence, as well as the covalent binding of the enzyme during electrochemical immobilization.